Albumin replacement solutions are poorly available for use in dogs. A recent retrospective by Culler et al (2019) in the Journal of Veterinary Emergency and Critical Care described the use of Cryo-supernatant (Cryo-S) as a constant rate infusion for albumin replacement in critically ill dogs.

Cryo-S is a by-product made during the production of Cryo-precipitate and contains more albumin in a g/ml basis than Fresh Frozen Plasma. It is also significantly cheaper ml for ml.

Dogs in the study received an average total dose of 31ml/kg at a mean rate of 1.8ml/kg/hr for a median of 16 hours (range 11-121). This was associated with a mean increase of albumin from 15.4g/l to 21g/l. Dogs that received a higher rate of Cryo-S infusion had a bigger increase in albumin.

Based on this study, it seems that Cryo-S may be a viable product for use in hypoalbuminaemic dogs to increase albumin concentration. Large volumes are required - based on this study a 10kg dog would have received 310ml of Cryo-S which is just over two units (each Cryo-S unit contains a minimum of 140ml). This is significantly cheaper than the equivalent volume of Fresh Frozen Plasma.


Culler, Christine & Iazbik, Maria & Guillaumin, Julien. (2017). Comparison of albumin, colloid osmotic pressure, von Willebrand factor, and coagulation factors in canine cryopoor plasma, cryoprecipitate, and fresh frozen plasma: Albumin and coagulation factors in plasma products. Journal of Veterinary Emergency and Critical Care. 27. 10.1111/vec.12671

Ropski, M. K., Guillaumin, J. , Monnig, A. A., Townsend, K. and McLoughlin, M. A. (2017). Use of cryopoor plasma for albumin replacement and continuous antimicrobial infusion for treatment of septic peritonitis in a dog. Journal of Veterinary Emergency and Critical Care. 27: 348-356. doi: 10.1111/vec.12583

Culler, CA, Balakrishnan, A, Yaxley, PE, Guillaumin, J. (2019). Clinical use of cryopoor plasma continuous rate infusion in critically ill, hypoalbuminemic dogs. Journal of Veterinary Emergency and Critical Care. 29: 314– 320.